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Title:

Visualizing the activation of encephalitogenic T cells in the ileal lamina propria by in vivo two-photon imaging.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Bauer, Isabel J; Fang, Ping; Lämmle, Katrin F; Tyystjärvi, Sofia; Alterauge, Dominik; Baumjohann, Dirk; Yoon, Hongsup; Korn, Thomas; Wekerle, Hartmut; Kawakami, Naoto
Abstract:
Autoreactive encephalitogenic T cells exist in the healthy immune repertoire but need a trigger to induce CNS inflammation. The underlying mechanisms remain elusive, whereby microbiota were shown to be involved in the manifestation of CNS autoimmunity. Here, we used intravital imaging to explore how microbiota affect the T cells as trigger of CNS inflammation. Encephalitogenic CD4+ T cells transduced with the calcium-sensing protein Twitch-2B showed calcium signaling with higher frequency than p...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2023
Journal volume:
120
Journal issue:
30
Fulltext / DOI:
doi:10.1073/pnas.2302697120
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37467267
Print-ISSN:
0027-8424
TUM Institution:
Molekulare Immunologie (Prof. Knolle)
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