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Title:

IL-23 stabilizes an effector Treg cell program in the tumor microenvironment.

Document type:
Journal Article
Author(s):
Wertheimer, Tobias; Zwicky, Pascale; Rindlisbacher, Lukas; Sparano, Colin; Vermeer, Marijne; de Melo, Bruno Marcel Silva; Haftmann, Claudia; Rückert, Tamina; Sethi, Aakriti; Schärli, Stefanie; Huber, Anna; Ingelfinger, Florian; Xu, Caroline; Kim, Daehong; Häne, Philipp; Fonseca da Silva, André; Muschaweckh, Andreas; Nunez, Nicolas; Krishnarajah, Sinduya; Köhler, Natalie; Zeiser, Robert; Oukka, Mohamed; Korn, Thomas; Tugues, Sonia; Becher, Burkhard
Abstract:
Interleukin-23 (IL-23) is a proinflammatory cytokine mainly produced by myeloid cells that promotes tumor growth in various preclinical cancer models and correlates with adverse outcomes. However, as to how IL-23 fuels tumor growth is unclear. Here, we found tumor-associated macrophages to be the main source of IL-23 in mouse and human tumor microenvironments. Among IL-23-sensing cells, we identified a subset of tumor-infiltrating regulatory T (Treg) cells that display a highly suppressive pheno...     »
Journal title abbreviation:
Nat Immunol
Year:
2024
Journal volume:
25
Journal issue:
3
Pages contribution:
512-524
Fulltext / DOI:
doi:10.1038/s41590-024-01755-7
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/38356059
Print-ISSN:
1529-2908
TUM Institution:
Molekulare Immunologie (Prof. Knolle)
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