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Title:

Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.

Document type:
Journal Article
Author(s):
Schmidt, Henrik; Raj, Timsse; O'Neill, Thomas J; Muschaweckh, Andreas; Giesert, Florian; Negraschus, Arlinda; Hoefig, Kai P; Behrens, Gesine; Esser, Lena; Baumann, Christina; Feederle, Regina; Plaza-Sirvent, Carlos; Geerlof, Arie; Gewies, Andreas; Isay, Sophie E; Ruland, Jürgen; Schmitz, Ingo; Wurst, Wolfgang; Korn, Thomas; Krappmann, Daniel; Heissmeyer, Vigo
Abstract:
Constitutive activation of the MALT1 paracaspase in conventional T cells of Malt1TBM/TBM (TRAF6 Binding Mutant = TBM) mice causes fatal inflammation and autoimmunity, but the involved targets and underlying molecular mechanisms are unknown. We genetically rendered a single MALT1 substrate, the RNA-binding protein (RBP) Roquin-1, insensitive to MALT1 cleavage. These Rc3h1Mins/Mins mice showed normal immune homeostasis. Combining Rc3h1Mins/Mins alleles with those encoding for constitutively active...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2023
Journal volume:
120
Journal issue:
48
Fulltext / DOI:
doi:10.1073/pnas.2309205120
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37988467
Print-ISSN:
0027-8424
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie (Prof. Ruland); Klinik und Poliklinik für Neurologie (Prof. Hemmer); Molekulare Immunologie (Prof. Knolle)
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