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Title:

The glioblastoma multiforme tumor site promotes the commitment of tumor-infiltrating lymphocytes to the TH17 lineage in humans.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Mitsdoerffer, Meike; Aly, Lilian; Barz, Melanie; Engleitner, Thomas; Sie, Christopher; Delbridge, Claire; Lepennetier, Gildas; Öllinger, Rupert; Pfaller, Monika; Wiestler, Benedikt; Rad, Roland; Meyer, Bernhard; Knier, Benjamin; Schmidt-Graf, Friederike; Gempt, Jens; Korn, Thomas
Abstract:
Although glioblastoma multiforme (GBM) is not an invariably cold tumor, checkpoint inhibition has largely failed in GBM. In order to investigate T cell-intrinsic properties that contribute to the resistance of GBM to endogenous or therapeutically enhanced adaptive immune responses, we sorted CD4+ and CD8+ T cells from the peripheral blood, normal-appearing brain tissue, and tumor bed of nine treatment-naive patients with GBM. Bulk RNA sequencing of highly pure T cell populations from these diffe...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2022
Journal volume:
119
Journal issue:
34
Fulltext / DOI:
doi:10.1073/pnas.2206208119
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35969754
Print-ISSN:
0027-8424
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Klinik und Poliklinik für Neurochirurgie (Prof. Meyer); Klinik und Poliklinik für Neurologie (Prof. Hemmer); Molekulare Immunologie (Prof. Knolle); Professur für AI for Image-Guided Diagnosis and Therapy (Prof. Wiestler); Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad); Professur für Neuroradiologie (Prof. Zimmer)
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