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Titel:

From Leflunomide to Teriflunomide: Drug Development and Immunosuppressive Oral Drugs in the Treatment of Multiple Sclerosis.

Dokumenttyp:
Journal Article
Autor(en):
Aly, Lilian; Hemmer, Bernhard; Korn, Thomas
Abstract:
Immunosuppressive drugs have been used in the treatment of multiple sclerosis (MS) for a long time. Today, orally available second generation immunosuppressive agents have been approved or are filed for licensing as MS therapeutics. Due to semi-selective targeting of cellular processes, these second-generation immunosuppressive compounds might rather be immunomodulatory. For example, Teriflunomide inhibits the de novo pyrimidine synthesis and thus only targets rapidly proliferating cells, includ...     »
Zeitschriftentitel:
Curr Neuropharmacol
Jahr:
2017
Band / Volume:
15
Heft / Issue:
6
Seitenangaben Beitrag:
874-891
Sprache:
eng
Volltext / DOI:
doi:10.2174/1570159X14666161208151525
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27928949
Print-ISSN:
1570-159X
TUM Einrichtung:
Molekulare Immunologie (Prof. Knolle); Neurologische Klinik und Poliklinik
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