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Title:

CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis.

Document type:
Journal Article
Author(s):
Barthels, Christian; Ogrinc, Ana; Steyer, Verena; Meier, Stefanie; Simon, Ferdinand; Wimmer, Maria; Blutke, Andreas; Straub, Tobias; Zimber-Strobl, Ursula; Lutgens, Esther; Marconi, Peggy; Ohnmacht, Caspar; Garzetti, Debora; Stecher, Bärbel; Brocker, Thomas
Abstract:
Immune homeostasis in intestinal tissues depends on the generation of regulatory T (Treg) cells. CD103+ dendritic cells (DCs) acquire microbiota-derived material from the gut lumen for transport to draining lymph nodes and generation of receptor-related orphan γt+ (RORγt+) Helios--induced Treg (iTreg) cells. Here we show CD40-signalling as a microbe-independent signal that can induce migration of CD103+ DCs from the lamina propria (LP) to the mesenteric lymph nodes. Transgenic mice with constitu...     »
Journal title abbreviation:
Nat Commun
Year:
2017
Journal volume:
8
Pages contribution:
14715
Language:
eng
Fulltext / DOI:
doi:10.1038/ncomms14715
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28276457
Print-ISSN:
2041-1723
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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