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Titel:

Cytochrome P450s in human immune cells regulate IL-22 and c-Kit via an AHR feedback loop.

Dokumenttyp:
Journal Article; Article
Autor(en):
Effner, Renate; Hiller, Julia; Eyerich, Stefanie; Traidl-Hoffmann, Claudia; Brockow, Knut; Triggiani, Massimo; Behrendt, Heidrun; Schmidt-Weber, Carsten B; Buters, Jeroen T M
Abstract:
The mechanisms how environmental compounds influence the human immune system are unknown. The environmentally sensitive transcription factor aryl hydrocarbon receptor (AHR) has immune-modulating functions and responds to small molecules. Cytochrome P4501 enzymes (CYP1) act downstream of the AHR and metabolize small molecules. However, it is currently unknown whether CYP1 activity is relevant for immune modulation. We studied the interdependence of CYP1 and AHR in human primary immune cells using...     »
Zeitschriftentitel:
Sci Rep
Jahr:
2017
Band / Volume:
7
Seitenangaben Beitrag:
44005
Sprache:
eng
Volltext / DOI:
doi:10.1038/srep44005
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28276465
Print-ISSN:
2045-2322
TUM Einrichtung:
Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber)
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