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Title:

Multicenter matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) identifies proteomic differences in breast-cancer-associated stroma.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Dekker, Tim J A; Balluff, Benjamin D; Jones, Emrys A; Schöne, Cédrik D; Schmitt, Manfred; Aubele, Michaela; Kroep, Judith R; Smit, Vincent T H B M; Tollenaar, Rob A E M; Mesker, Wilma E; Walch, Axel; McDonnell, Liam A
Abstract:
MALDI mass spectrometry imaging (MSI) has rapidly established itself as a powerful biomarker discovery tool. To date, no formal investigation has assessed the center-to-center comparability of MALDI MSI experiments, an essential step for it to develop into a new diagnostic method. To test such capabilities, we have performed a multicenter study focused on biomarkers of stromal activation in breast cancer. MALDI MSI experiments were performed in two centers using independent tissue banks, infrast...     »
Journal title abbreviation:
J Proteome Res
Year:
2014
Journal volume:
13
Journal issue:
11
Pages contribution:
4730-8
Language:
eng
Fulltext / DOI:
doi:10.1021/pr500253j
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24762205
Print-ISSN:
1535-3893
TUM Institution:
Frauenklinik und Poliklinik
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