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Titel:

uPA and PAI-1 as biomarkers in breast cancer: validated for clinical use in level-of-evidence-1 studies.

Dokumenttyp:
Journal Article; Review
Autor(en):
Duffy, Michael J; McGowan, Patricia M; Harbeck, Nadia; Thomssen, Christoph; Schmitt, Manfred
Abstract:
Urokinase plasminogen activator (uPA) is an extracellular matrix-degrading protease involved in cancer invasion and metastasis, interacting with plasminogen activator inhibitor-1 (PAI-1), which was originally identified as a blood-derived endogenous fast-acting inhibitor of uPA. At concentrations found in tumor tissue, however, both PAI-1 and uPA promote tumor progression and metastasis. Consistent with the causative role of uPA and PAI-1 in cancer dissemination, several retrospective and prospe...     »
Zeitschriftentitel:
Breast Cancer Res
Jahr:
2014
Band / Volume:
16
Heft / Issue:
4
Seitenangaben Beitrag:
428
Sprache:
eng
Volltext / DOI:
doi:10.1186/s13058-014-0428-4
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25677449
Print-ISSN:
1465-542X
TUM Einrichtung:
Frauenklinik und Poliklinik
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