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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Chmielewski, Stefan; Olejnik, Adam; Sikorski, Krzysztof; Pelisek, Jaroslav; B?aszczyk, Katarzyna; Aoqui, Cristiane; Nowicka, Hanna; Zernecke, Alma; Heemann, Uwe; Wesoly, Joanna; Baumann, Marcus; Bluyssen, Hans A R
Title:
STAT1-dependent signal integration between IFN? and TLR4 in vascular cells reflect pro-atherogenic responses in human atherosclerosis.
Abstract:
Signal integration between IFN? and TLRs in immune cells has been associated with the host defense against pathogens and injury, with a predominant role of STAT1. We hypothesize that STAT1-dependent transcriptional changes in vascular cells involved in cross-talk between IFN? and TLR4, reflect pro-atherogenic responses in human atherosclerosis. Genome-wide investigation identified a set of STAT1-dependent genes that were synergistically affected by interactions between IFN? and TLR4 in VSMCs. Th...     »
Journal title abbreviation:
PLoS ONE
Year:
2014
Journal volume:
9
Journal issue:
12
Pages contribution:
e113318
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0113318
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25478796
Print-ISSN:
1932-6203
TUM Institution:
Fachgebiet Gefäßchirurgie (Prof. Eckstein); Fachgebiet Nephrologie (Prof. Heemann)
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