User: Guest  Login
Document type:
Journal Article; Article
Author(s):
Werk, A N; Lefeldt, S; Bruckmueller, H; Hemmrich-Stanisak, G; Franke, A; Roos, M; Küchle, C; Steubl, D; Schmaderer, C; Bräsen, J H; Heemann, U; Cascorbi, I; Renders, L
Title:
Identification and Characterization of a Defective CYP3A4 Genotype in a Kidney Transplant Patient With Severely Diminished Tacrolimus Clearance.
Abstract:
Cytochrome P450 3A4 (CYP3A4) is a major drug-metabolizing enzyme that is widely investigated. So far, no homozygous inactive variant has been described. We report on a 19-year-old kidney transplant patient suffering from Alport syndrome, who experienced unexpected high tacrolimus plasma trough levels during immunosuppressant therapy. Because nonadherence, liver failure, or drug-drug interactions could be excluded, we hypothesized a diminished metabolism of the drug caused by mutations in the mai...     »
Journal title abbreviation:
Clin Pharmacol Ther
Year:
2014
Journal volume:
95
Journal issue:
4
Pages contribution:
416-22
Language:
eng
Fulltext / DOI:
doi:10.1038/clpt.2013.210
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24126681
Print-ISSN:
0009-9236
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann)
 BibTeX