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Titel:

Identification and Characterization of a Defective CYP3A4 Genotype in a Kidney Transplant Patient With Severely Diminished Tacrolimus Clearance.

Dokumenttyp:
Journal Article; Article
Autor(en):
Werk, A N; Lefeldt, S; Bruckmueller, H; Hemmrich-Stanisak, G; Franke, A; Roos, M; Küchle, C; Steubl, D; Schmaderer, C; Bräsen, J H; Heemann, U; Cascorbi, I; Renders, L
Abstract:
Cytochrome P450 3A4 (CYP3A4) is a major drug-metabolizing enzyme that is widely investigated. So far, no homozygous inactive variant has been described. We report on a 19-year-old kidney transplant patient suffering from Alport syndrome, who experienced unexpected high tacrolimus plasma trough levels during immunosuppressant therapy. Because nonadherence, liver failure, or drug-drug interactions could be excluded, we hypothesized a diminished metabolism of the drug caused by mutations in the mai...     »
Zeitschriftentitel:
Clin Pharmacol Ther
Jahr:
2014
Band / Volume:
95
Heft / Issue:
4
Seitenangaben Beitrag:
416-22
Sprache:
eng
Volltext / DOI:
doi:10.1038/clpt.2013.210
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24126681
Print-ISSN:
0009-9236
TUM Einrichtung:
Fachgebiet Nephrologie (Prof. Heemann)
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