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Titel:

XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Yabal, Monica; Müller, Nicole; Adler, Heiko; Knies, Nathalie; Groß, Christina J; Damgaard, Rune Busk; Kanegane, Hirokazu; Ringelhan, Marc; Kaufmann, Thomas; Heikenwälder, Mathias; Strasser, Andreas; Groß, Olaf; Ruland, Jürgen; Peschel, Christian; Gyrd-Hansen, Mads; Jost, Philipp J
Abstract:
X-linked inhibitor of apoptosis protein (XIAP) has been identified as a potent regulator of innate immune responses, and loss-of-function mutations in XIAP cause the development of the X-linked lymphoproliferative syndrome type 2 (XLP-2) in humans. Using gene-targeted mice, we show that loss of XIAP or deletion of its RING domain lead to excessive cell death and IL-1? secretion from dendritic cells triggered by diverse Toll-like receptor stimuli. Aberrant IL-1? secretion is TNF dependent and req...     »
Zeitschriftentitel:
Cell Rep
Jahr:
2014
Band / Volume:
7
Heft / Issue:
6
Seitenangaben Beitrag:
1796-808
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.celrep.2014.05.008
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24882010
Print-ISSN:
2211-1247
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Klinische Chemie und Pathobiochemie; Institut für Virologie
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