Amine-free approach toward N-toluenesulfonyl amidine construction: a phosphite-mediated Beckmann-like coupling of oximes and p-toluenesulfonyl azide.

Titel:: Amine-free approach toward N-toluenesulfonyl amidine construction: a phosphite-mediated Beckmann-like coupling of oximes and p-toluenesulfonyl azide.
Dokumenttyp:: Journal Article
Autor(en):: Fleury, Lauren M; Wilson, Erin E; Vogt, Monika; Fan, Tiffany J; Oliver, Allen G; Ashfeld, Brandon L
Abstract:: Atom hopping: A chlorophosphite-mediated Beckmann ligation of oximes and p-toluenesulfonyl azide gives access to N-sulfonyl phosphoramidines in good to excellent yields. The reaction proceeds under exceptionally mild conditions and constitutes a bioorthogonal approach toward amidines by avoiding the use of amines and transition-metal catalysts. dmp-ol=3,3-dimethylpropanediol.
Zeitschriftentitel:: Angew Chem Int Ed Engl
Jahr:: 2013
Band / Volume:: 52
Heft / Issue:: 44
Seitenangaben Beitrag:: 11589-93
Sprache:: eng
Volltext / DOI:: doi:10.1002/anie.201305141
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/24038711
Print-ISSN:: 1433-7851
TUM Einrichtung:: Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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