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Title:

The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
von Figura, Guido; Fukuda, Akihisa; Roy, Nilotpal; Liku, Muluye E; Morris Iv, John P; Kim, Grace E; Russ, Holger A; Firpo, Matthew A; Mulvihill, Sean J; Dawson, David W; Ferrer, Jorge; Mueller, William F; Busch, Anke; Hertel, Klemens J; Hebrok, Matthias
Abstract:
Pancreatic ductal adenocarcinoma (PDA) develops through distinct precursor lesions, including pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasia (IPMN). However, genetic features resulting in IPMN-associated PDA (IPMN-PDA) versus PanIN-associated PDA (PanIN-PDA) are largely unknown. Here we find that loss of Brg1, a core subunit of SWI/SNF chromatin remodelling complexes, cooperates with oncogenic Kras to form cystic neoplastic lesions that resemble human I...     »
Journal title abbreviation:
Nat Cell Biol
Year:
2014
Journal volume:
16
Journal issue:
3
Pages contribution:
255-67
Language:
eng
Fulltext / DOI:
doi:10.1038/ncb2916
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24561622
Print-ISSN:
1465-7392
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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