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Title:

Chromatin landscapes of retroviral and transposon integration profiles.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
de Jong, Johann; Akhtar, Waseem; Badhai, Jitendra; Rust, Alistair G; Rad, Roland; Hilkens, John; Berns, Anton; van Lohuizen, Maarten; Wessels, Lodewyk F A; de Ridder, Jeroen
Abstract:
The ability of retroviruses and transposons to insert their genetic material into host DNA makes them widely used tools in molecular biology, cancer research and gene therapy. However, these systems have biases that may strongly affect research outcomes. To address this issue, we generated very large datasets consisting of ~ 120,000 to ~ 180,000 unselected integrations in the mouse genome for the Sleeping Beauty (SB) and piggyBac (PB) transposons, and the Mouse Mammary Tumor Virus (MMTV). We ana...     »
Journal title abbreviation:
PLoS Genet
Year:
2014
Journal volume:
10
Journal issue:
4
Pages contribution:
e1004250
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pgen.1004250
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24721906
Print-ISSN:
1553-7390
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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