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Title:

Organ size control is dominant over Rb family inactivation to restrict proliferation in vivo.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Ehmer, Ursula; Zmoos, Anne-Flore; Auerbach, Raymond K; Vaka, Dedeepya; Butte, Atul J; Kay, Mark A; Sage, Julien
Abstract:
In mammals, a cell's decision to divide is thought to be under the control of the Rb/E2F pathway. We previously found that inactivation of the Rb family of cell cycle inhibitors (Rb, p107, and p130) in quiescent liver progenitors leads to uncontrolled division and cancer initiation. Here, we show that, in contrast, deletion of the entire Rb gene family in mature hepatocytes is not sufficient for their long-term proliferation. The cell cycle block in Rb family mutant hepatocytes is independent of...     »
Journal title abbreviation:
Cell Rep
Year:
2014
Journal volume:
8
Journal issue:
2
Pages contribution:
371-81
Language:
eng
Fulltext / DOI:
doi:10.1016/j.celrep.2014.06.025
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25017070
Print-ISSN:
2211-1247
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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