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Title:

MiR-221/-222 differentiate prognostic groups in advanced breast cancers and influence cell invasion.

Document type:
Journal Article
Author(s):
Falkenberg, N; Anastasov, N; Rappl, K; Braselmann, H; Auer, G; Walch, A; Huber, M; Höfig, I; Schmitt, M; Höfler, H; Atkinson, MJ; Aubele, M
Abstract:
Background:MiR-221/-222 are frequently overexpressed in breast cancer and are associated with increased malignancy. The specific modification of microRNAs (miRNAs) expression could be a promising strategy in breast cancer therapy, leading to the suppression of tumourigenic processes in tumour cells.Methods:MiR-221/-222 expressions were analysed in 86 breast cancer tissues by quantitative RT-PCR and tested for correlation with immunohistochemistry data and clinical follow-up. In vitro assays were...     »
Journal title abbreviation:
Br J Cancer
Year:
2013
Journal volume:
109
Journal issue:
10
Pages contribution:
2714-23
Language:
eng
Fulltext / DOI:
doi:10.1038/bjc.2013.625
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24129242
Print-ISSN:
0007-0920
TUM Institution:
Frauenklinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
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