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Title:

PPAR alpha: a novel radiation target in locally exposed Mus musculus heart revealed by quantitative proteomics.

Document type:
Journal Article
Author(s):
Azimzadeh, O; Sievert, W; Sarioglu, H; Yentrapalli, R; Barjaktarovic, Z; Sriharshan, A; Ueffing, M; Janik, D; Aichler, M; Atkinson, MJ; Multhoff, G; Tapio, S
Abstract:
Radiation exposure of the thorax is associated with a markedly increased risk of cardiac morbidity and mortality with a latency period of decades. Although many studies have confirmed the damaging effect of ionizing radiation on the myocardium and cardiac endothelial structure and function, the molecular mechanism behind this damage is not yet elucidated. Peroxisome proliferator-activated receptor alpha (PPAR alpha), a transcriptional regulator of lipid metabolism in heart tissue, has recently r...     »
Journal title abbreviation:
J Proteome Res
Year:
2013
Journal volume:
12
Journal issue:
6
Pages contribution:
2700-14
Language:
eng
Fulltext / DOI:
doi:10.1021/pr400071g
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23560462
Print-ISSN:
1535-3893
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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