Tjalma, Wiebren A; Fiander, Alison; Reich, Olaf; Powell, Ned; Nowakowski, Andrzej M; Kirschner, Benny; Koiss, Robert; O'Leary, John; Joura, Elmar A; Rosenlund, Mats; Colau, Brigitte; Schledermann, Doris; Kukk, Kersti; Damaskou, Vasileia; Repanti, Maria; Vladareanu, Radu; Kolomiets, Larisa; Savicheva, Alevtina; Shipitsyna, Elena; Ordi, Jaume; Molijn, Anco; Quint, Wim; Raillard, Alice; Rosillon, Dominique; De Souza, Sabrina Collas; Jenkins, David; Holl, Katsiaryna; HERACLES/SCALE Study Group; Horvat, R; Six, L; Spacek, M; Krikelda, F; Praet, M; Simon, P; De Vos, B; Kodet, R; Rob, L; Hrdlickova-Stachova, P; Nenutil, R; Rotterova, P; Sevcik, L; Dvorackova, J; Pluta, M; Robova, H; Kaliskova, E; Junge, J; Herslov, M; Vaasna, I; Oro, S; Diedrich, K; Gieseking, F; Woelber, L; Schmalfeldt, B; Beckmann, M W; Mehlhorn, H; Hanusch, C; Kirchner, T; Bergauer, F; Dannecker, C; Mayr, D; Kölbl, H; Euteneuer, B; Nilges, K; Petry, K U; Liebrich, C; Nenning, H; Eisenhofer-Wolff, C; Apostolikas, N; Markaki, S; Zaraboukas, T; Pantzaki, A; Papaspirou, I; Zairi, E; Pournara, E; Mosonyi, A; Barna, T; Pal, M; Martin, C; Sheils, O; Power, G; Hagen, B; Lømo, J; Iversen, O E; Bertelsen, B; Haugland, H; Thoresen, S; Basta, A; Jach, R; Tomaszewska, R; Kotarski, J; Barczynski, B; Lyszcz, R; Maj, A; Pawlowska-Wakowicz, B; Ksiazek, A; Pinto, I; Simões, T; Belo, A I; Brito, M J; Gonçalves, L D P; Carichas, M; Nicula, F; Chiricu??, Ion; Onofriescu, M; Mociulschi, R; Constantinescu, D; Minkina, G; Scherbakov, M; Castro Sánchez, M; Cortés Lambea, L; Torné Blade, A; Cambronero Martínez, R; Cuschieri, K; Blaikie, S; Crochard, A; Pirog, E C; McCluggage, G     «

Tjalma, Wiebren A; Fiander, Alison; Reich, Olaf; Powell, Ned; Nowakowski, Andrzej M; Kirschner, Benny; Koiss, Robert; O'Leary, John; Joura, Elmar A; Rosenlund, Mats; Colau, Brigitte; Schledermann, Doris; Kukk, Kersti; Damaskou, Vasileia; Repanti, Maria; Vladareanu, Radu; Kolomiets, Larisa; Savicheva, Alevtina; Shipitsyna, Elena; Ordi, Jaume; Molijn, Anco; Quint, Wim; Raillard, Alice; Rosillon, Dominique; De Souza, Sabrina Collas; Jenkins, David; Holl, Katsiaryna; HERACLES/SCALE Study Group; Horv...     »

Knowledge of differences in human papillomavirus (HPV)-type prevalence between high-grade cervical intraepithelial neoplasia (HG-CIN) and invasive cervical cancer (ICC) is crucial for understanding the natural history of HPV-infected cervical lesions and the potential impact of HPV vaccination on cervical cancer prevention. More than 6,000 women diagnosed with HG-CIN or ICC from 17 European countries were enrolled in two parallel cross-sectional studies (108288/108290). Centralised histopathology review and standardised HPV-DNA typing were applied to formalin-fixed paraffin-embedded cervical specimens dated 2001-2008. The pooled prevalence of individual HPV types was estimated using meta-analytic methods. A total of 3,103 women were diagnosed with HG-CIN and a total of 3,162 with ICC (median ages: 34 and 49 years, respectively), of which 98.5 and 91.8% were HPV-positive, respectively. The most common HPV types in women with HG-CIN were HPV16/33/31 (59.9/10.5/9.0%) and in ICC were HPV16/18/45 (63.3/15.2/5.3%). In squamous cell carcinomas, HPV16/18/33 were most frequent (66.2/10.8/5.3%), and in adenocarcinomas, HPV16/18/45 (54.2/40.4/8.3%). The prevalence of HPV16/18/45 was 1.1/3.5/2.5 times higher in ICC than in HG-CIN. The difference in age at diagnosis between CIN3 and squamous cervical cancer for HPV18 (9 years) was significantly less compared to HPV31/33/'other' (23/20/17 years), and for HPV45 (1 year) than HPV16/31/33/'other' (15/23/20/17 years). In Europe, HPV16 predominates in both HG-CIN and ICC, whereas HPV18/45 are associated with a low median age of ICC. HPV18/45 are more frequent in ICC than HG-CIN and associated with a high median age of HG-CIN, with a narrow age interval between HG-CIN and ICC detection. These findings support the need for primary prevention of HPV16/18/45-related cervical lesions.     «

Knowledge of differences in human papillomavirus (HPV)-type prevalence between high-grade cervical intraepithelial neoplasia (HG-CIN) and invasive cervical cancer (ICC) is crucial for understanding the natural history of HPV-infected cervical lesions and the potential impact of HPV vaccination on cervical cancer prevention. More than 6,000 women diagnosed with HG-CIN or ICC from 17 European countries were enrolled in two parallel cross-sectional studies (108288/108290). Centralised histopatholog...     »