Benutzer: Gast  Login
Titel:

Somatic copy number changes in DPYD are associated with lower risk of recurrence in triple-negative breast cancers.

Dokumenttyp:
Journal Article
Autor(en):
Gross, E; Meul, C; Raab, S; Propping, C; Avril, S; Aubele, M; Gkazepis, A; Schuster, T; Grebenchtchikov, N; Schmitt, M; Kiechle, M; Meijer, J; Vijzelaar, R; Meindl, A; van Kuilenburg, AB
Abstract:
Background:Genomic rearrangements at the fragile site FRA1E may disrupt the dihydropyrimidine dehydrogenase gene (DPYD) which is involved in 5-fluorouracil (5-FU) catabolism. In triple-negative breast cancer (TNBC), a subtype of breast cancer frequently deficient in DNA repair, we have investigated the susceptibility to acquire copy number variations (CNVs) in DPYD and evaluated their impact on standard adjuvant treatment.Methods:DPYD CNVs were analysed in 106 TNBC tumour specimens using multipl...     »
Zeitschriftentitel:
Br J Cancer
Jahr:
2013
Band / Volume:
109
Heft / Issue:
9
Seitenangaben Beitrag:
2347-55
Sprache:
eng
Volltext / DOI:
doi:10.1038/bjc.2013.621
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24104963
Print-ISSN:
0007-0920
TUM Einrichtung:
Frauenklinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Statistik und Epidemiologie
 BibTeX