Impact of expression of the uPA system in sarcomas.
Dokumenttyp:
Journal Article
Autor(en):
Taubert, H; Magdolen, V; Kotzsch, M
Abstract:
The uPA system mainly comprises the urokinase-type plasminogen activator uPA, the cell-surface receptor uPA receptor and the inhibitor PAI-1. Its clinical and prognostic impact especially in breast cancer is well investigated. In this short report, we summarize the published data describing expression of uPA, PAI-1 and uPA receptor and their relevance to clinical and survival data in sarcomas underlining their impact as tumor biomarkers in this tumor type as well.