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Titel:

Effects of simultaneous knockdown of HER2 and PTK6 on malignancy and tumor progression in human breast cancer cells.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Ludyga, N; Anastasov, N; Rosemann, M; Seiler, J; Lohmann, N; Braselmann, H; Mengele, K; Schmitt, M; Höfler, H; Aubele, M
Abstract:
Breast cancer is the most common malignancy in women of the Western world. One prominent feature of breast cancer is the co- and overexpression of HER2 and protein tyrosine kinase 6 (PTK6). According to the current clinical cancer therapy guidelines, HER2-overexpressing tumors are routinely treated with trastuzumab, a humanized monoclonal antibody targeting HER2. Approximately, 30% of HER2-overexpressing breast tumors at least initially respond to the anti-HER2 therapy, but a subgroup of these t...     »
Zeitschriftentitel:
Mol Cancer Res
Jahr:
2013
Band / Volume:
11
Heft / Issue:
4
Seitenangaben Beitrag:
381-92
Sprache:
eng
Volltext / DOI:
doi:10.1158/1541-7786.MCR-12-0378
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23364537
Print-ISSN:
1541-7786
TUM Einrichtung:
Frauenklinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
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