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Titel:

Sorafenib in combination with intensive chemotherapy in elderly patients with acute myeloid leukemia: results from a randomized, placebo-controlled trial.

Dokumenttyp:
Journal Article; Randomized Controlled Trial
Autor(en):
Serve, Hubert; Krug, Utz; Wagner, Ruth; Sauerland, M Cristina; Heinecke, Achim; Brunnberg, Uta; Schaich, Markus; Ottmann, Oliver; Duyster, Justus; Wandt, Hannes; Fischer, Thomas; Giagounidis, Aristoteles; Neubauer, Andreas; Reichle, Albrecht; Aulitzky, Walter; Noppeney, Richard; Blau, Igor; Kunzmann, Volker; Stuhlmann, Reingard; Krämer, Alwin; Kreuzer, Karl-Anton; Brandts, Christian; Steffen, Björn; Thiede, Christian; Müller-Tidow, Carsten; Ehninger, Gerhard; Berdel, Wolfgang E
Abstract:
The prognosis of elderly patients with acute myeloid leukemia (AML) is still dismal even with intensive chemotherapy. In this trial, we compared the antileukemic activity of standard induction and consolidation therapy with or without the addition of the kinase inhibitor sorafenib in elderly patients with AML.All patients received standard cytarabine and daunorubicin induction (7+3 regimen) and up to two cycles of intermediate-dose cytarabine consolidation. Two hundred one patients were equally...     »
Zeitschriftentitel:
J Clin Oncol
Jahr:
2013
Band / Volume:
31
Heft / Issue:
25
Seitenangaben Beitrag:
3110-8
Sprache:
eng
Volltext / DOI:
doi:10.1200/JCO.2012.46.4990
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23897964
Print-ISSN:
0732-183X
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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