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Titel:

Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Shakya, Reena; Gonda, Tamas; Quante, Michael; Salas, Martha; Kim, Samuel; Brooks, Jenna; Hirsch, Steffen; Davies, Justine; Cullo, Angelica; Olive, Kenneth; Wang, Timothy C; Szabolcs, Matthias; Tycko, Benjamin; Ludwig, Thomas
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that resists current treatments. To test epigenetic therapy against this cancer, we used the DNA demethylating drug 5-aza-2'-deoxycytidine (DAC) in an aggressive mouse model of stromal rich PDAC (KPC-Brca1 mice). In untreated tumors, we found globally decreased 5-methyl-cytosine (5-mC) in malignant epithelial cells and in cancer-associated myofibroblasts (CAF), along with increased amounts of 5-hydroxymethyl-cytosine (5-HmC) in CAFs,...     »
Zeitschriftentitel:
Cancer Res
Jahr:
2013
Band / Volume:
73
Heft / Issue:
2
Seitenangaben Beitrag:
885-96
Sprache:
eng
Volltext / DOI:
doi:10.1158/0008-5472.CAN-12-1880
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23204224
Print-ISSN:
0008-5472
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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