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Title:

Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Shakya, Reena; Gonda, Tamas; Quante, Michael; Salas, Martha; Kim, Samuel; Brooks, Jenna; Hirsch, Steffen; Davies, Justine; Cullo, Angelica; Olive, Kenneth; Wang, Timothy C; Szabolcs, Matthias; Tycko, Benjamin; Ludwig, Thomas
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that resists current treatments. To test epigenetic therapy against this cancer, we used the DNA demethylating drug 5-aza-2'-deoxycytidine (DAC) in an aggressive mouse model of stromal rich PDAC (KPC-Brca1 mice). In untreated tumors, we found globally decreased 5-methyl-cytosine (5-mC) in malignant epithelial cells and in cancer-associated myofibroblasts (CAF), along with increased amounts of 5-hydroxymethyl-cytosine (5-HmC) in CAFs,...     »
Journal title abbreviation:
Cancer Res
Year:
2013
Journal volume:
73
Journal issue:
2
Pages contribution:
885-96
Language:
eng
Fulltext / DOI:
doi:10.1158/0008-5472.CAN-12-1880
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23204224
Print-ISSN:
0008-5472
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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