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Title:

Immunosuppression with 4SC-101, a novel inhibitor of dihydroorotate dehydrogenase, in a rat model of renal transplantation.

Document type:
Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Rusai, K; Schmaderer, C; Baumann, M; Chmielewski, S; Prokai, A; Kis, E; Szabo, AJ; Leban, J; Doblhofer, R; Ammendola, A; Lutz, J; Heemann, U
Abstract:
4SC-101 is a novel dihydroorotate dehydrogenase inhibitor and a blocker of interleukin (IL)-17 secretion with beneficial effects in experimental lupus and inflammatory bowel disease. Its immunomodulatory effect on acute kidney rejection is not known; therefore, in this study, the impact of 4SC-101 was examined in a rat model of acute kidney rejection.The kidneys of Brown-Norway rats were orthotopically transplanted into bilaterally nephrectomized Lewis recipients. Allograft recipients were admi...     »
Journal title abbreviation:
Transplantation
Year:
2012
Journal volume:
93
Journal issue:
11
Pages contribution:
1101-7
Language:
eng
Fulltext / DOI:
doi:10.1097/TP.0b013e31824fd861
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22609757
Print-ISSN:
0041-1337
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann)
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