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Title:

Intravenous application of an anticalin dramatically lowers plasma digoxin levels and reduces its toxic effects in rats.

Document type:
Journal Article
Author(s):
Eyer, F; Steimer, W; Nitzsche, T; Jung, N; Neuberger, H; Müller, C; Schlapschy, M; Zilker, T; Skerra, A
Abstract:
Lipocalins tailored with high affinity for prescribed ligands, so-called anticalins, constitute promising candidates as antidotes. Here, we present an animal study to investigate both pharmacokinetic and clinical effects of an anticalin specific for the digitalis compound digoxin. Intravenous digoxin (2.5-50 ?g/kg/min) was administered to rats until first changes in the ECG occurred (dose finding study) or a priori for 30 min (kinetic study). The anticalin DigA16(H86N), dubbed DigiCal, was admin...     »
Journal title abbreviation:
Toxicol Appl Pharmacol
Year:
2012
Journal volume:
263
Journal issue:
3
Pages contribution:
352-9
Language:
eng
Fulltext / DOI:
doi:10.1016/j.taap.2012.07.009
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22820422
Print-ISSN:
0041-008X
TUM Institution:
2. Medizinische Klinik Toxikologische Abteilung (alt) (Prof. Zilker); Institut für Klinische Chemie und Pathobiochemie
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