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Titel:

Intravenous application of an anticalin dramatically lowers plasma digoxin levels and reduces its toxic effects in rats.

Dokumenttyp:
Journal Article
Autor(en):
Eyer, F; Steimer, W; Nitzsche, T; Jung, N; Neuberger, H; Müller, C; Schlapschy, M; Zilker, T; Skerra, A
Abstract:
Lipocalins tailored with high affinity for prescribed ligands, so-called anticalins, constitute promising candidates as antidotes. Here, we present an animal study to investigate both pharmacokinetic and clinical effects of an anticalin specific for the digitalis compound digoxin. Intravenous digoxin (2.5-50 ?g/kg/min) was administered to rats until first changes in the ECG occurred (dose finding study) or a priori for 30 min (kinetic study). The anticalin DigA16(H86N), dubbed DigiCal, was admin...     »
Zeitschriftentitel:
Toxicol Appl Pharmacol
Jahr:
2012
Band / Volume:
263
Heft / Issue:
3
Seitenangaben Beitrag:
352-9
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.taap.2012.07.009
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22820422
Print-ISSN:
0041-008X
TUM Einrichtung:
2. Medizinische Klinik Toxikologische Abteilung (alt) (Prof. Zilker); Institut für Klinische Chemie und Pathobiochemie
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