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Titel:

Phenotyping of pulmonary carcinoids and a Ki-67-based grading approach.

Dokumenttyp:
journal article
Autor(en):
Zahel, T; Krysa, S; Herpel, E; Stenzinger, A; Goeppert, B; Schirmacher, P; Hoffmann, H; Schnabel, PA; Warth, A
Abstract:
Pulmonary carcinoids (PC) are separated into typical (TC) and atypical carcinoids (ATC). However, the biological behavior cannot be reliably predicted, and in small biopsies differential diagnosis can be challenging. To provide a basis for a grading approach, we analyzed mitoses and the proliferative index (PI; Ki-67) of 200 PC specimens (TC: n = 114; ATC: n = 86). To define suitable diagnostic and to screen for putative therapeutic markers, CD56, CD57, CD99, CD117, TTF-1, synaptophysin, chrom...     »
Zeitschriftentitel:
Virchows Arch
Jahr:
2012
Band / Volume:
460
Heft / Issue:
3
Seitenangaben Beitrag:
299-308
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22293945
Print-ISSN:
0945-6317
TUM Einrichtung:
Institut für Radiologie
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