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Title:

Fractalkine is expressed in early and advanced atherosclerotic lesions and supports monocyte recruitment via CX3CR1.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Stolla, M; Pelisek, J; von Brühl, ML; Schafer, A; Barocke, V; Heider, P; Lorenz, M; Tirniceriu, A; Steinhart, A; Bauersachs, J; Bray, PF; Massberg, S; Schulz, C
Abstract:
Fractalkine (CX3CL1, FKN) is expressed in the inflamed vascular wall and absence of FKN reduces atherogenesis. Whether FKN is expressed throughout all stages of atherosclerotic disease and whether it directly contributes to monocyte recruitment to atherosclerotic lesions is not known. We collected human atherosclerotic plaque material and blood samples from patients with carotid artery disease undergoing endarterectomy. Plaques were analyzed by immunohistochemistry and qPCR. We found that FKN is...     »
Journal title abbreviation:
PLoS ONE
Year:
2012
Journal volume:
7
Journal issue:
8
Pages contribution:
e43572
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0043572
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22916279
Print-ISSN:
1932-6203
TUM Institution:
Fachgebiet Gefäßchirurgie (Prof. Eckstein); Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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