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Title:

Auto-antigenic protein-DNA complexes stimulate plasmacytoid dendritic cells to promote atherosclerosis.

Document type:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Doring, Y; Manthey, HD; Drechsler, M; Lievens, D; Megens, RT; Soehnlein, O; Busch, M; Manca, M; Koenen, RR; Pelisek, J; Daemen, MJ; Lutgens, E; Zenke, M; Binder, CJ; Weber, C; Zernecke, A
Abstract:
Inflammation has been closely linked to auto-immunogenic processes in atherosclerosis. Plasmacytoid dendritic cells (pDCs) are specialized to produce type-I interferons in response to pathogenic single-stranded nucleic acids, but can also sense self-DNA released from dying cells or in neutrophil extracellular traps complexed to the antimicrobial peptide Cramp/LL37 in autoimmune disease. However, the exact role of pDCs in atherosclerosis remains elusive.Here we demonstrate that pDCs can be detect...     »
Journal title abbreviation:
Circulation
Year:
2012
Journal volume:
125
Journal issue:
13
Pages contribution:
1673-83
Language:
eng
Fulltext / DOI:
doi:10.1161/CIRCULATIONAHA.111.046755
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22388324
Print-ISSN:
0009-7322
TUM Institution:
Fachgebiet Gefäßchirurgie (Prof. Eckstein)
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