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Titel:

Novel fatty acid gentamicin salts as slow-release drug carrier systems for anti-infective protection of vascular biomaterials.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Obermeier, A; Matl, FD; Schwabe, J; Zimmermann, A; Kühn, KD; Lakemeier, S; von Eisenhart-Rothe, R; Stemberger, A; Burgkart, R
Abstract:
Infections of vascular prostheses are still a major risk in surgery. The current work presents an in vitro evaluation of novel slow release antibiotic coatings based on new gentamicin fatty acid salts for polytetrafluoroethylene grafts. These grafts were coated with gentamicin sodium dodecyl sulfate, gentamicin laurate and gentamicin palmitate. Drug release kinetics, anti-infective characteristics, biocompatibility and haemocompatibility of developed coatings were compared to commercially availa...     »
Zeitschriftentitel:
J Mater Sci Mater Med
Jahr:
2012
Band / Volume:
23
Heft / Issue:
7
Seitenangaben Beitrag:
1675-83
Sprache:
eng
Volltext / DOI:
doi:10.1007/s10856-012-4631-5
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22476651
Print-ISSN:
0957-4530
TUM Einrichtung:
Fachgebiet Gefäßchirurgie (Prof. Eckstein); Klinik und Poliklinik für Orthopädie und Sportorthopädie
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