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Titel:

Comparison of 6q25 breast cancer hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC).

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Intramural; Article
Autor(en):
Hein, R; Maranian, M; Hopper, JL; Kapuscinski, MK; Southey, MC; Park, DJ; Schmidt, MK; Broeks, A; Hogervorst, FB; Bueno-de-Mesquit, HB; Muir, KR; Lophatananon, A; Rattanamongkongul, S; Puttawibul, P; Fasching, PA; Hein, A; Ekici, AB; Beckmann, MW; Fletcher, O; Johnson, N; Dos Santos Silva, I; Peto, J; Sawyer, E; Tomlinson, I; Kerin, M; Miller, N; Marmee, F; Schneeweiss, A; Sohn, C; Burwinkel, B; Guénel, P; Cordina-Duverger, E; Menegaux, F; Truong, T; Bojesen, SE; Nordestgaard, BG; Flyger, H; Mil...     »
Abstract:
The 6q25.1 locus was first identified via a genome-wide association study (GWAS) in Chinese women and marked by single nucleotide polymorphism (SNP) rs2046210, approximately 180 Kb upstream of ESR1. There have been conflicting reports about the association of this locus with breast cancer in Europeans, and a GWAS in Europeans identified a different SNP, tagged here by rs12662670. We examined the associations of both SNPs in up to 61,689 cases and 58,822 controls from forty-four studies collabora...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2012
Band / Volume:
7
Heft / Issue:
8
Seitenangaben Beitrag:
e42380
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0042380
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22879957
Print-ISSN:
1932-6203
TUM Einrichtung:
Frauenklinik und Poliklinik
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