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Titel:

MALDI imaging mass spectrometry for in situ proteomic analysis of preneoplastic lesions in pancreatic cancer.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Grüner, BM; Hahne, H; Mazur, PK; Trajkovic-Arsic, M; Maier, S; Esposito, I; Kalideris, E; Michalski, CW; Kleeff, J; Rauser, S; Schmid, RM; Küster, B; Walch, A; Siveke, JT
Abstract:
The identification of new biomarkers for preneoplastic pancreatic lesions (PanINs, IPMNs) and early pancreatic ductal adenocarcinoma (PDAC) is crucial due to the diseases high mortality rate upon late detection. To address this task we used the novel technique of matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) on genetically engineered mouse models (GEM) of pancreatic cancer. Various GEM were analyzed with MALDI IMS to investigate the peptide/protein-expressio...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2012
Band / Volume:
7
Heft / Issue:
6
Seitenangaben Beitrag:
e39424
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0039424
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22761793
Print-ISSN:
1932-6203
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Allgemeine Pathologie und Pathologische Anatomie
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