User: Guest  Login
Less Searchfields
Simple search
Title:

Hepatocyte-specific mutation of both NF-?B RelA and STAT3 abrogates the acute phase response in mice.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Quinton, LJ; Blahna, MT; Jones, MR; Allen, E; Ferrari, JD; Hilliard, KL; Zhang, X; Sabharwal, V; Algul, H; Akira, S; Schmid, RM; Pelton, SI; Spira, A; Mizgerd, JP
Abstract:
The acute phase response is an evolutionarily conserved reaction in which physiological stress triggers the liver to remodel the blood proteome. Although thought to be involved in immune defense, the net biological effect of the acute phase response remains unknown. As the acute phase response is stimulated by diverse cytokines that activate either NF-?B or STAT3, we hypothesized that it could be eliminated by hepatocyte-specific interruption of both transcription factors. Here, we report that t...     »
Journal title abbreviation:
J Clin Invest
Year:
2012
Journal volume:
122
Journal issue:
5
Pages contribution:
1758-63
Language:
eng
Fulltext / DOI:
doi:10.1172/JCI59408
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22466650
Print-ISSN:
0021-9738
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
 BibTeX