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Title:

Pan-histone deacetylase inhibitor panobinostat sensitizes gastric cancer cells to anthracyclines via induction of CITED2.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Regel, I; Merkl, L; Friedrich, T; Burgermeister, E; Zimmermann, W; Einwächter, H; Herrmann, K; Langer, R; Röcken, C; Hofheinz, R; Schmid, R; Ebert, MP
Abstract:
Chemotherapy modestly prolongs survival of patients with advanced gastric cancer, but strategies are needed to increase its efficacy. Histone deacetylase (HDAC) inhibitors modify chromatin and can block cancer cell proliferation and promote apoptosis.Gastric cancer cell lines were incubated with the HDAC inhibitor LBH589 (Panobinostat, Novartis, Germany); levels of proliferation, apoptosis, histone acetylation, and gene expression were determined. We identified factors downstream of HDAC that r...     »
Journal title abbreviation:
Gastroenterology
Year:
2012
Journal volume:
143
Journal issue:
1
Pages contribution:
99-109.e10
Language:
eng
Fulltext / DOI:
doi:10.1053/j.gastro.2012.03.035
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22465428
Print-ISSN:
0016-5085
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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