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Title:

MYC directs transcription of MCL1 and eIF4E genes to control sensitivity of gastric cancer cells toward HDAC inhibitors.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Labisso, WL; Wirth, M; Stojanovic, N; Stauber, RH; Schnieke, A; Schmid, RM; Krämer, OH; Saur, D; Schneider, G
Abstract:
Histone deacetylases (HDACs) control fundamental physiological processes such as proliferation and differentiation. HDAC inhibitors (HDACi) induce cell cycle arrest and apoptosis of tumor cells. Therefore, they represent promising cancer therapeutics that appear particularly useful in combination therapies. Although HDACi are tested in current clinical trials, the molecular mechanisms modulating the cellular responses toward HDACi are incompletely understood. To gain insight into pathways that l...     »
Journal title abbreviation:
Cell Cycle
Year:
2012
Journal volume:
11
Journal issue:
8
Pages contribution:
1593-602
Language:
eng
Fulltext / DOI:
doi:10.4161/cc.20008
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22456335
Print-ISSN:
1538-4101
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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