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Title:

Regulation of RLR-mediated innate immune signaling--it is all about keeping the balance.

Document type:
Journal Article; Review
Author(s):
Eisenächer, K; Krug, A
Abstract:
The current view of cytoplasmic RNA-mediated innate immune signaling involves the differential activation of the RNA helicases retinoic acid-inducible gene 1 (RIG-I), melanoma differentiation-associated gene 5 (MDA5) and laboratory of genetics and physiology-2 (LGP2) by distinct RNA viruses. RIG-I, MDA5 and LGP2 form the RIG-I like receptor family (RLR). Since the initial characterization of the RLRs rapid progress has been made in the understanding of the molecular mechanisms that upon virus in...     »
Journal title abbreviation:
Eur J Cell Biol
Year:
2012
Journal volume:
91
Journal issue:
1
Pages contribution:
36-47
Language:
eng
Fulltext / DOI:
doi:10.1016/j.ejcb.2011.01.011
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21481967
Print-ISSN:
0171-9335
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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