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Titel:

Hepatocyte-specific mutation of both NF-?B RelA and STAT3 abrogates the acute phase response in mice.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Quinton, LJ; Blahna, MT; Jones, MR; Allen, E; Ferrari, JD; Hilliard, KL; Zhang, X; Sabharwal, V; Algul, H; Akira, S; Schmid, RM; Pelton, SI; Spira, A; Mizgerd, JP
Abstract:
The acute phase response is an evolutionarily conserved reaction in which physiological stress triggers the liver to remodel the blood proteome. Although thought to be involved in immune defense, the net biological effect of the acute phase response remains unknown. As the acute phase response is stimulated by diverse cytokines that activate either NF-?B or STAT3, we hypothesized that it could be eliminated by hepatocyte-specific interruption of both transcription factors. Here, we report that t...     »
Zeitschriftentitel:
J Clin Invest
Jahr:
2012
Band / Volume:
122
Heft / Issue:
5
Seitenangaben Beitrag:
1758-63
Sprache:
eng
Volltext / DOI:
doi:10.1172/JCI59408
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22466650
Print-ISSN:
0021-9738
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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