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Title:

Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Hamidi, T; Algul, H; Cano, CE; Sandi, MJ; Molejon, MI; Riemann, M; Calvo, EL; Lomberk, G; Dagorn, JC; Weih, F; Urrutia, R; Schmid, RM; Iovanna, JL
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) has the lowest survival rate of all cancers and shows remarkable resistance to cell stress. Nuclear protein 1 (Nupr1), which mediates stress response in the pancreas, is frequently upregulated in pancreatic cancer. Here, we report that Nupr1 plays an essential role in pancreatic tumorigenesis. In a mouse model of pancreatic cancer with constitutively expressed oncogenic Kras(G12D), we found that loss of Nupr1 protected from the development of pancreatic in...     »
Journal title abbreviation:
J Clin Invest
Year:
2012
Journal volume:
122
Journal issue:
6
Pages contribution:
2092-103
Language:
eng
Fulltext / DOI:
doi:10.1172/JCI60144
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22565310
Print-ISSN:
0021-9738
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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