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Title:

Neuronal cGMP kinase I is essential for stimulation of duodenal bicarbonate secretion by luminal acid.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Singh, AK; Spiessberger, B; Zheng, W; Xiao, F; Lukowski, R; Wegener, JW; Weinmeister, P; Saur, D; Klein, S; Schemann, M; Krueger, D; Seidler, U; Hofmann, F
Abstract:
Brief contact of the duodenal mucosa with luminal acid elicits a long-lasting bicarbonate (HCO(3)(-)) secretory response, which is believed to be the primary protective mechanism against mucosal damage. Here, we show that cGMP-dependent protein kinase type I-knockout (cGKI(-/-)) mice are unable to respond to a physiological H(+) stimulus with a HCO(3)(-) secretory response and spontaneously develop duodenal ulcerations. Smooth muscle-selective cGKI knock-in rescued the motility disturbance but n...     »
Journal title abbreviation:
FASEB J
Year:
2012
Journal volume:
26
Journal issue:
4
Pages contribution:
1745-54
Language:
eng
Fulltext / DOI:
doi:10.1096/fj.11-200394
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22253479
Print-ISSN:
0892-6638
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Pharmakologie und Toxikologie
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