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Titel:

MYC directs transcription of MCL1 and eIF4E genes to control sensitivity of gastric cancer cells toward HDAC inhibitors.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Labisso, WL; Wirth, M; Stojanovic, N; Stauber, RH; Schnieke, A; Schmid, RM; Krämer, OH; Saur, D; Schneider, G
Abstract:
Histone deacetylases (HDACs) control fundamental physiological processes such as proliferation and differentiation. HDAC inhibitors (HDACi) induce cell cycle arrest and apoptosis of tumor cells. Therefore, they represent promising cancer therapeutics that appear particularly useful in combination therapies. Although HDACi are tested in current clinical trials, the molecular mechanisms modulating the cellular responses toward HDACi are incompletely understood. To gain insight into pathways that l...     »
Zeitschriftentitel:
Cell Cycle
Jahr:
2012
Band / Volume:
11
Heft / Issue:
8
Seitenangaben Beitrag:
1593-602
Sprache:
eng
Volltext / DOI:
doi:10.4161/cc.20008
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22456335
Print-ISSN:
1538-4101
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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