Login
- Document type:
- Journal Article; Research Support, Non-U.S. Gov't
- Author(s):
- Flisikowska, T; Merkl, C; Landmann, M; Eser, S; Rezaei, N; Cui, X; Kurome, M; Zakhartchenko, V; Kessler, B; Wieland, H; Rottmann, O; Schmid, RM; Schneider, G; Kind, A; Wolf, E; Saur, D; Schnieke, A
- Title:
- A porcine model of familial adenomatous polyposis.
- Abstract:
- We created gene-targeted pigs with mutations in the adenomatous polyposis coli (APC) gene (APC) that are orthologous to those responsible for human familial adenomatous polyposis (FAP). One-year-old pigs with the APC(1311) mutation (orthologous to human APC(1309)) have aberrant crypt foci and low- and high-grade dysplastic adenomas in the large intestine, similar to the precancerous lesions that develop in patients with FAP. Dysplastic adenomas accumulate ?-catenin and lose heterozygosity of APC... »
- Journal title abbreviation:
- Gastroenterology
- Year:
- 2012
- Journal volume:
- 143
- Journal issue:
- 5
- Pages contribution:
- 1173-5.e1-7
- Language:
- eng
- Fulltext / DOI:
- doi:10.1053/j.gastro.2012.07.110
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/22864254
- Print-ISSN:
- 0016-5085
- TUM Institution:
- II. Medizinische Klinik und Poliklinik (Gastroenterologie)
BibTeX