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Titel:

Pan-histone deacetylase inhibitor panobinostat sensitizes gastric cancer cells to anthracyclines via induction of CITED2.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Regel, I; Merkl, L; Friedrich, T; Burgermeister, E; Zimmermann, W; Einwächter, H; Herrmann, K; Langer, R; Röcken, C; Hofheinz, R; Schmid, R; Ebert, MP
Abstract:
Chemotherapy modestly prolongs survival of patients with advanced gastric cancer, but strategies are needed to increase its efficacy. Histone deacetylase (HDAC) inhibitors modify chromatin and can block cancer cell proliferation and promote apoptosis.Gastric cancer cell lines were incubated with the HDAC inhibitor LBH589 (Panobinostat, Novartis, Germany); levels of proliferation, apoptosis, histone acetylation, and gene expression were determined. We identified factors downstream of HDAC that r...     »
Zeitschriftentitel:
Gastroenterology
Jahr:
2012
Band / Volume:
143
Heft / Issue:
1
Seitenangaben Beitrag:
99-109.e10
Sprache:
eng
Volltext / DOI:
doi:10.1053/j.gastro.2012.03.035
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22465428
Print-ISSN:
0016-5085
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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