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Titel:

Expression and clinicopathological significance of notch signaling and cell-fate genes in biliary tract cancer.

Dokumenttyp:
Journal Article; Article
Autor(en):
Mazur, PK; Riener, MO; Jochum, W; Kristiansen, G; Weber, A; Schmid, RM; Siveke, JT
Abstract:
Biliary tract cancer (BTC) is a fatal cancer originating from epithelial cells of the intra- and extra-hepatic biliary duct system and the gallbladder. Genes and pathways regulating stem and progenitor cells as well as cell-fate decisions are increasingly recognized in tumorigenesis. We evaluated the expression of Notch1, Notch2, and HES1 (hairy and enhancer of split 1), as well as the biliary cell-fate regulators SOX9 (SRY (sex determining region Y)-box 9) and HNF1? (hepatocyte nuclear factor 1...     »
Zeitschriftentitel:
Am J Gastroenterol
Jahr:
2012
Band / Volume:
107
Heft / Issue:
1
Seitenangaben Beitrag:
126-35
Sprache:
eng
Volltext / DOI:
doi:10.1038/ajg.2011.305
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21931375
Print-ISSN:
0002-9270
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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