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Title:

Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines.

Document type:
Journal Article; Article
Author(s):
Heindl, S; Eggenstein, E; Keller, S; Kneissl, J; Keller, G; Mutze, K; Rauser, S; Gasteiger, G; Drexler, I; Hapfelmeier, A; Höfler, H; Luber, B
Abstract:
The therapeutic activity of the epidermal growth factor receptor (EGFR)-directed monoclonal antibody cetuximab in gastric cancer is currently being investigated. Reliable biomarkers for the identification of patients who are likely to benefit from the treatment are not available. The aim of the study was to examine the drug sensitivity of five gastric cancer cell lines towards cetuximab as a single agent and to establish predictive markers for chemosensitivity in this cell culture model. The eff...     »
Journal title abbreviation:
J Cancer Res Clin Oncol
Year:
2012
Journal volume:
138
Journal issue:
5
Pages contribution:
843-58
Language:
eng
Fulltext / DOI:
doi:10.1007/s00432-011-1128-4
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22290393
Print-ISSN:
0171-5216
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Statistik und Epidemiologie; Institut für Virologie
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