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Title:

Mineralocorticoid receptor antagonism and aldosterone synthesis inhibition do not improve glomerulosclerosis and renal interstitial fibrosis in a model of chronic kidney allograft injury.

Document type:
Journal Article; Article
Author(s):
Lahmer, T; Hermans, R; Schmaderer, C; Chang, J; Stock, K; Lutz, J; Heemann, U; Baumann, M
Abstract:
Chronic allograft injury (CAI) is a major cause of late graft failure with a multifactorial pathogenesis; however, in different experiments an inhibition of the renin-angiotensin system by angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers ameliorated the progression of chronic renal disease. Different concepts supposed that aldosterone is involved in development and/or progression of renal diseases via interaction with a non-epithelial mineralocorticoid recept...     »
Journal title abbreviation:
Kidney Blood Press Res
Year:
2012
Journal volume:
35
Journal issue:
6
Pages contribution:
561-7
Language:
eng
Fulltext / DOI:
doi:10.1159/000339649
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22890233
Print-ISSN:
1420-4096
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann)
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