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Title:

A Novel Pulsatile Bioreactor for Mechanical Stimulation of Tissue Engineered Cardiac Constructs

Author(s):
Hollweck, T., Akra, B., Haussler, S., Uberfuhr, P., Schmitz, C., Pfeifer, S., Eblenkamp, M., Wintermantel, E., Eissner, G.
Abstract:
After myocardial infarction, the implantation of stem cell seeded scaffolds on the ischemic zone represents a promising strategy for restoration of heart function. However, mechanical integrity and functionality of tissue engineered constructs need to be determined prior to implantation. Therefore, in this study a novel pulsatile bioreactor mimicking the myocardial contraction was developed to analyze the behavior of mesenchymal stem cells derived from umbilical cord tissue (UCMSC) colonized on...     »
Keywords:
Practical, Experimental/ biomechanics biomedical materials bioreactors cardiology cellular biophysics glass polymers silicones stainless steel tissue engineering/ pulsatile bioreactor tissue engineered cardiac construct mechanical stimulation myocardial infarction stem cell seeded scaffold implantation ischemic zone heart function restoration tissue engineered construct mechanical integrity tissue engineered construct functionality myocardial contraction mimicry mesenchymal stem cell behavior um...     »
Journal title:
Journal of Functional Biomaterials
Year:
2011
Journal volume:
2
Journal issue:
3
Pages contribution:
107-118
Fulltext / DOI:
doi:10.3390/jfb2030107
WWW:
http://www.mdpi.com/2079-4983/2/3/107
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