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Titel:

DNA immunization against amyloid beta 42 has high potential as safe therapy for Alzheimer's disease as it diminishes antigen-specific Th1 and Th17 cell proliferation.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Autor(en):
Lambracht-Washington, D; Qu, BX; Fu, M; Anderson, LD; Stüve, O; Eagar, TN; Rosenberg, RN
Abstract:
The pathogenesis of Alzheimer's disease (AD) has been strongly associated with the accumulation of amyloid beta (A?) peptides in brain, and immunotherapy targeting A? provides potential for AD prevention. A clinical trial in which AD patients were immunized with A?42 peptide was stopped when 6% of participants showed meningoencephalitis, apparently due to an inflammatory Th1 immune response. Previously, we and other have shown that A?42 DNA vaccination via gene gun generates a Th2 cellular immun...     »
Zeitschriftentitel:
Cell Mol Neurobiol
Jahr:
2011
Band / Volume:
31
Heft / Issue:
6
Seitenangaben Beitrag:
867-74
Sprache:
eng
Volltext / DOI:
doi:10.1007/s10571-011-9680-7
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21625960
Print-ISSN:
0272-4340
TUM Einrichtung:
Neurologische Klinik und Poliklinik
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